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Reichart Lab - Research

Gene editing

Nucleic acid therapies are potential therapeutic approaches for cardiovascular genetic diseases. DNA modification can be achieved with genome editors delivered by vectors like adeno-associated viruses or liponanoparticles. CRISPR-based tools such as base or prime editing allow – even in post-mitotic cells – precise and efficient genome editing enabling modification of monogenetic cardiovascular diseases.


Three different types of CRISPR-based tools: nucleases, base and prime editors. Modified from Nature Biotechnology, 38, pages 824–44 (2020)