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Conzelmann - Molecular Biology of Negative Strand RNA Viruses

Research Topics

  • Rabies Virus Neuron-Biology
  • Trans-synaptic Tracing of Neurons
  • Innate Immune Response to RNA Viruses

We are studying negative strand RNA viruses like rabies and measles virus to learn how they exploit and trick the cellular machineries. Key technologies include genetic engineering of RNA viruses (reverse genetics) and CRISPR-based editing of entire host cell genomes. The knowledge of details of virus replication and host-cell interplay is required to develop novel antiviral strategies to exploit viruses as biomedical tools or vaccines. Read more...

Selected Publications

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization.
Hennrich AA, Sawatsky B, Santos-Mandujano R, Banda DH, Oberhuber M, Schopf A, Pfaffinger V, Wittwer K, Riedel C, Pfaller CK, Conzelmann KK.
PLoS Pathog. 2021 Apr 21;17(4):e1009064. doi: 10.1371/journal.ppat.1009064. PubMed

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ.
Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. PubMed

Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells.
Oberhuber M, Schopf A, Hennrich AA, Santos-Mandujano R, Huhn AG, Seitz S, Riedel C, Conzelmann KK.
Viruses. 2021 Aug 30;13(9):1726. doi: 10.3390/v13091726. PubMed

Budding of rabies virus particles in the absence of the spike glycoprotein.
Mebatsion T, Konig M, Conzelmann KK.
Cell. 1996 Mar 22;84(6):941-51. PubMed

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