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Förstemann Lab - Publications

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RNA polymerase II is recruited to DNA double-strand breaks for dilncRNA transcription in Drosophila.
Böttcher R, Schmidts I, Nitschko V, Duric P, Förstemann K.
RNA Biol. 2021 Dec 29:1-10. doi: 10.1080/15476286.2021.2014694. PubMed

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis.
Lenz J, Liefke R, Funk J, Shoup S, Nist A, Stiewe T, Schulz R, Tokusumi Y, Albert L, Raifer H, Förstemann K, Vázquez O, Tokusumi T, Fossett N, Brehm A.
PLoS Genet. 2021 Feb 18;17(2):e1009318. doi: 10.1371/journal.pgen.1009318. PubMed


Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila.
Nitschko V, Kunzelmann S, Fröhlich T, Arnold GJ, Förstemann K.
Nucleic Acids Res. 2020 Feb 6. pii: gkaa072. doi: 10.1093/nar/gkaa072. PubMed



Sex-specific programming effects of parental obesity in pre-implantation embryonic development.
Hedegger K, Philippou-Massier J, Krebs S, Blum H, Kunzelmann S, Förstemann K, Gimpfl M, Roscher AA, Ensenauer R, Wolf E, Dahlhoff M.
Int J Obes (Lond). 2019 Nov 27. doi: 10.1038/s41366-019-0494-x. PubMed



Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M.
Nucleic Acids Res. 2017 Dec 1;45(21):12536-12550. doi: 10.1093/nar/gkx886. PubMed

Reversible perturbations of gene regulation after genome editing in Drosophila cells.
Kunzelmann S, Förstemann K.
PLoS One. 2017 Jun 28;12(6):e0180135. doi: 10.1371/journal.pone.0180135. eCollection 2017. PubMed

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.
Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M and Förstemann K.
PLoS Genetics. 2017 2017 Jun 19;13(6):e1006861. doi: 10.1371/journal.pgen.1006861. eCollection 2017 Jun. PubMed



Homology directed repair is unaffected by the absence of siRNAs in Drosophila melanogaster.
Schmidts I, Böttcher R, Mirkovic-Hösle M, Förstemann K.
Nucleic Acids Res. 2016 Sep 30;44(17):8261-71. doi: 10.1093/nar/gkw570. Epub 2016 Jun 27. PubMed 

A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
Wissel S, Kieser A, Yasugi T, Duchek P, Roitinger E, Gokcezade J, Steinmann V, Gaul U, Mechtler K, Förstemann K, Knoblich JA, Neumüller RA.
G3 (Bethesda). 2016 Aug 9;6(8):2467-78. doi: 10.1534/g3.116.028571. PubMed

A Comprehensive Toolbox for Genome Editing in Cultured Drosophila melanogaster Cells.
Kunzelmann S, Böttcher R, Schmidts I, Förstemann K.
G3 (Bethesda). 2016 Jun 1;6(6):1777-85. doi: 10.1534/g3.116.028241. PubMed



Analysis of endo-siRNAs in Drosophila.
Elmer K, Helfer S, Mirkovic-Hösle M, Förstemann K.
Methods Mol Biol. 2014;1173:33-49. doi: 10.1007/978-1-4939-0931-5_4. PubMed

Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells.
Böttcher R, Hollmann M, Merk K, Nitschko V, Obermaier C, Philippou-Massier J, Wieland I, Gaul U, Förstemann K.
Nucleic Acids Res. 2014 Jun;42(11):e89. doi: 10.1093/nar/gku289. Epub 2014 Apr 19. PubMed

Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.
Mirkovic-Hösle M, Förstemann K.
PLoS One. 2014 Jan 13;9(1):e84994. doi: 10.1371/journal.pone.0084994. eCollection 2014. PubMed



Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan.
Esslinger SM, Schwalb B, Helfer S, Michalik KM, Witte H, Maier KC, Martin D, Michalke B, Tresch A, Cramer P, Förstemann K.
RNA Biol. 2013 Jun;10(6):1042-56. doi: 10.4161/rna.24810. Epub 2013 Apr 30. PubMed



Functional characterization of Drosophila microRNAs by a novel in vivo library.
Schertel C, Rutishauser T, Förstemann K, Basler K.
Genetics. 2012 Dec;192(4):1543-52. doi: 10.1534/genetics.112.145383. Epub 2012 Oct 10. PubMed

A small RNA response at DNA ends in Drosophila.
Michalik KM, Böttcher R, Förstemann K.
Nucleic Acids Res. 2012 Oct;40(19):9596-603. doi: 10.1093/nar/gks711. Epub 2012 Jul 30. PubMed

Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte.
Aumiller V, Graebsch A, Kremmer E, Niessing D, Förstemann K.
RNA Biol. 2012 May;9(5):633-43. doi: 10.4161/rna.19760. Epub 2012 May 1. PubMed

Murine cytomegalovirus infection of cultured mouse cells induces expression of miR-7a.
Dittmer A, Förstemann K.
J Gen Virol. 2012 Jul;93(Pt 7):1537-47. doi: 10.1099/vir.0.041822-0. Epub 2012 Mar 21. PubMed

AU-rich element-mediated mRNA decay can occur independently of the miRNA machinery in mouse embryonic fibroblasts and Drosophila S2-cells.
Helfer S, Schott J, Stoecklin G, Förstemann K.
PLoS One. 2012;7(1):e28907. doi: 10.1371/journal.pone.0028907. Epub 2012 Jan 13. PubMed



Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.
Hartig JV, Förstemann K.
Nucleic Acids Res. 2011 May;39(9):3836-51. doi: 10.1093/nar/gkq1324. Epub 2011 Jan 17. PubMed



Transposon defense in Drosophila somatic cells: a model for distinction of self and non-self in the genome.
Förstemann K.
RNA Biol. 2010 Mar-Apr;7(2):158-61. Epub 2010 Mar 28. PubMed



Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences.
Hartig JV, Esslinger S, Böttcher R, Saito K, Förstemann K.
EMBO J. 2009 Oct 7;28(19):2932-44. doi: 10.1038/emboj.2009.220. Epub 2009 Jul 30. PubMed

MicroRNAs repress mainly through mRNA decay.
Esslinger S, Förstemann K.
Angew Chem Int Ed Engl. 2009;48(5):853-5. doi: 10.1002/anie.200805127. No abstract available. PubMed



Monitoring miRNA-mediated silencing in Drosophila melanogaster S2-cells.
Shah C, Förstemann K.
Biochim Biophys Acta. 2008 Nov;1779(11):766-72. doi: 10.1016/j.bbagrm.2008.06.008. Epub 2008 Jun 25. PubMed

Roles of microRNAs beyond development--metabolism and neural plasticity.
Aumiller V, Förstemann K.
Biochim Biophys Acta. 2008 Nov;1779(11):692-6. doi: 10.1016/j.bbagrm.2008.04.008. Epub 2008 May 2. Review. PubMed



Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.
Förstemann K*, Horwich MD*, Wee L, Tomari Y, Zamore PD.
Cell. 2007 Jul 27;130(2):287-97. PubMed

piRNAs--the ancient hunters of genome invaders.
Hartig JV, Tomari Y, Förstemann K.
Genes Dev. 2007 Jul 15;21(14):1707-13. Review. PubMed



The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.
Eugster A, Lanzuolo C, Bonneton M, Luciano P, Pollice A, Pulitzer JF, Stegberg E, Berthiau AS, Förstemann K, Corda Y, Lingner J, Géli V, Gilson E.
Nat Struct Mol Biol. 2006 Aug;13(8):734-9. Epub 2006 Jul 30. PubMed



Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.
Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD.
PLoS Biol. 2005 Jul;3(7):e236. Epub 2005 May 24. PubMed

Telomerase limits the extent of base pairing between template RNA and telomeric DNA.
Förstemann K, Lingner J.
EMBO Rep. 2005 Apr;6(4):361-6. PubMed



Yeast telomerase is specialized for C/A-rich RNA templates.
Förstemann K, Zaug AJ, Cech TR, Lingner J.
Nucleic Acids Res. 2003 Mar 15;31(6):1646-55. PubMed



Telomerase: biochemical considerations for enzyme and substrate.
Kelleher C, Teixeira MT, Förstemann K, Lingner J.
Trends Biochem Sci. 2002 Nov;27(11):572-9. Review. PubMed

Intracellular trafficking of yeast telomerase components.
Teixeira MT, Förstemann K, Gasser SM, Lingner J.
EMBO Rep. 2002 Jul;3(7):652-9. PubMed



Molecular basis for telomere repeat divergence in budding yeast.
Förstemann K, Lingner J.
Mol Cell Biol. 2001 Nov;21(21):7277-86. PubMed



Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres.
Förstemann K, Höss M, Lingner J.
Nucleic Acids Res. 2000 Jul 15;28(14):2690-4. PubMed