Gene Center Munich

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Förstemann Lab - Research

DNA and chromatin dependent processes are highly interconnected – transcription and DNA repair cross-talk to each other and both are influenced by the chromatin context. Our interest is the role of non-coding RNAs in genome surveillance and regulation, including small RNAs such as siRNAs and miRNAs but also other non-coding transcripts. The fruit fly Drosophila melanogaster is a particularly valuable model organism because it harbors a diverse collection of active transposable elements, a highly active endo-siRNA pathway providing a sequence-specific readout and it is very accessible with genetic, molecular biology and biochemical tools.