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Muenchhoff Lab - Research

HIV persistence in viral reservoirs

Despite major efforts current antiretroviral therapy is not curative. The major obstacle to an HIV cure is persistence of HIV in pools of latently and persistently infected cells. Potential therapeutic interventions aiming at an HIV cure depend on precise methods to quantify and study these viral reservoirs. Within the German Center for Infectious Diseases (DZIF) we are establishing a platform to characterize the HIV reservoir using a portfolio of different methods such as digital droplet PCR and optimized viral outgrowth assays. These assays are made available to other scientist and are used in our own studies of HIV infection in primary cell models.