Muenchhoff Lab - Research
- Research
- HIV persistence
- Immunopathogenesis of viral infections
- SARS-CoV-2 evolution
Immunopathogenesis of viral infections
The pathogenesis of viral infections is determined by highly variable degrees of inflammation and adaptive immunity resulting in a diverse spectrum of disease phenotypes. We are studying interactions of HIV and SARS-CoV-2 with the human immune system to delineate signatures that are associated with disease severity.
Together with our clinical colleagues (Johannes Hellmuth and Clemens Scherer) we established the COVID-19 Registerstudie des Klinikums der Universität München (CORKUM) which has recruited more than 1.000 COVID-19 patients so far (https://forschungsportal.med.uni-muenchen.de/corkum/). An extensive collection of diverse biospecimen from this well characterised cohort allows us to integrate molecular data (proteomics, transcriptomics, genomics) with deep clinical data to decipher differential disease trajectories. We are particularly interested in humoral and cellular immune responses in specific patient populations including immunocompromised hosts.