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Three new Publications

Read more about our latest research on the bacterial DNA double-strand break sensor Mre11-Rad50 homolog SbcCD, the structure of BCL10-MALT1 filaments, important for adaptive immune response and the structure of Swi/Snf2 remodeler Mot1 in the resting state:

sbccdThe bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions.

Saathoff JH, Käshammer L, Lammens K, Byrne RT, Hopfner KP.
Nucleic Acids Res. 2018 Oct 2. doi: 10.1093/nar/gky878. PubMed


maltMolecular architecture and regulation of BCL10-MALT1 filaments.

Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K.
Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8. PubMed


mot1Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state.

Butryn A, Woike S, Shetty SJ, Auble DT, Hopfner KP.
Elife. 2018 Oct 5;7. pii: e37774. doi: 10.7554/eLife.37774. PubMed