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Blum Lab - Genomics

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2021

Fusion gene detection by RNA sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements.
Kerbs P, Vosberg S, Krebs S, Graf A, Blum H, Swoboda A, Batcha AMN, Mansmann U, Metzler D, Heckman CA, Herold T, Greif PA.
Haematologica. 2021 Jun 17. doi: 10.3324/haematol.2021.278436. Epub ahead of print. PMID: 34134471. Pubmed

Differential gene regulation in DAPT-treated Hydra reveals candidate direct notch signalling targets.
Moneer J, Siebert S, Krebs S, Cazet J, Prexl A, Pan Q, Juliano C, Böttger A.
J Cell Sci. 2021 Jun 14:jcs.258768. doi: 10.1242/jcs.258768. Epub ahead of print. Pubmed

Liver Transplantation in a Patient after COVID-19 - rapid loss of antibodies and prolonged Viral RNA Shedding.
Niess H, Börner N, Muenchhoff M, Khatamzas E, Stangl M, Graf A, Girl P, Georgi E, Koliogiannis D, Denk G, Irlbeck M, Werner J, Guba M.
Am J Transplant. 2021 Apr;21(4):1629-1632. doi: 10.1111/ajt.16349. Epub 2020 Nov 2. PubMed

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation.
Buschle A, Mrozek-Gorska P, Cernilogar FM, Ettinger A, Pich D, Krebs S, Mocanu B, Blum H, Schotta G, Straub T, Hammerschmidt W.
Nucleic Acids Res. 2021 Apr 6;49(6):3217-3241. doi: 10.1093/nar/gkab099.  PubMed

ONT-based draft genome assembly and annotation of Alternaria atra.
Bonthala B, Small CS, Lutz MA, Graf A, Krebs S, Sepúlveda G, Stam R.
Mol Plant Microbe Interact. 2021 Mar 29. doi: 10.1094/MPMI-01-21-0016-A. Epub ahead of print. Pubmed

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones.
Kirstein N, Buschle A, Wu X, Krebs S, Blum H, Kremmer E, Vorberg IM, Hammerschmidt W, Lacroix L, Hyrien O, Audit B, Schepers A.
Elife. 2021 Mar 8;10:e62161. doi: 10.7554/eLife.62161. Epub ahead of print. Pubmed

Capture Sequencing to Explore and Map Rare Casein Variants in Goats.
Rahmatalla SA, Arends D, Said Ahmed A, Hassan LMA, Krebs S, Reissmann M, Brockmann GA.
Front Genet. 2021 Feb 23;12:620253. doi: 10.3389/fgene.2021.620253. Pubmed

Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2).
Pfaff F, Neubauer-Juric A, Krebs S, Hauser A, Singer S, Blum H, Hoffmann B.
Arch Virol. 2021 Feb;166(2):639-643. doi: 10.1007/s00705-020-04895-x. Epub 2020 Dec 14. Pubmed

Prospective Longitudinal Serosurvey of Health Care Workers in the First Wave of the SARS-CoV-2 Pandemic in a Quaternary Care Hospital in Munich, Germany.
Weinberger T, Steffen J, Osterman A, Mueller TT, Muenchhoff M, Wratil PR, Graf A, Krebs S, Quartucci C, Spaeth PM, Grabein B, Adorjan K, Blum H, Keppler OT, Klein M.
Clin Infect Dis. 2021 Jan 3:ciaa1935. doi: 10.1093/cid/ciaa1935. Epub ahead of print. Pubmed

2020

A de novo frameshift mutation in ZEB2 causes polledness, abnormal skull shape, small body stature and subfertility in Fleckvieh cattle.
Gehrke LJ, Upadhyay M, Heidrich K, Kunz E, Klaus-Halla D, Weber F, Zerbe H, Seichter D, Graf A, Krebs S, Blum H, Capitan A, Thaller G, Medugorac I.
Sci Rep. 2020 Oct 12;10(1):17032. doi: 10.1038/s41598-020-73807-5. PubMed

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses.
Mueller S, Lange S, Collins KAN, Krebs S, Blum H, Schneider G, Rad L, Saur D, Rad R.
Nat Commun. 2020 Sep 8;11(1):4474. doi: 10.1038/s41467-020-18095-3. PubMed

Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation.
Panagiotopoulos AL, Karguth N, Pavlou M, Böhm S, Gasparoni G, Walter J, Graf A, Blum H, Biel M, Riedmayr LM, Becirovic E.
Mol Ther Nucleic Acids. 2020 Sep 4;21:1050-1061. doi: 10.1016/j.omtn.2020.07.036. Epub 2020 Jul 31. PubMed

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.
Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O’Toole Á, Pereyaslov D, WHO European Region sequencing laboratories and GISAID EpiCoV group (..., Graf A, Muenchhoff M, Keppler OT, Krebs S, Blum H, ...) [577 coauthors].
Euro Surveill. 2020 Aug 13; 25(32): 2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410. PubMed

The First Draft Genome Assembly of Snow Sheep (Ovis nivicola).
Upadhyay M, Hauser A, Kunz E, Krebs S, Blum H, Dotsev A, Okhlopkov I, Bagirov V, Brem G, Zinovieva N, Medugorac I.
Genome Biol Evol. 2020 Aug 1;12(8):1330-1336. doi: 10.1093/gbe/evaa124. PubMed

An improved method for high-throughput quantification of autophagy in mammalian cells.
Koepke L, Winter B, Grenzner A, Regensburger K, Engelhart S, van der Merwe JA, Krebs S, Blum H, Kirchhoff F, Sparrer KMJ.
Sci Rep. 2020 Jul 22;10(1):12241. doi: 10.1038/s41598-020-68607-w. PubMed

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.
Wolfien M, Klatt D, Salybekov AA, Ii M, Komatsu-Horii M, Gaebel R, Philippou-Massier J, Schrinner E, Akimaru H, Akimaru E, David R, Garbade J, Gummert J, Haverich A, Hennig H, Iwasaki H, Kaminski A, Kawamoto A, Klopsch C, Kowallick JT, Krebs S, Nesteruk J, Reichenspurner H, Ritter C, Stamm C, Tani-Yokoyama A, Blum H, Wolkenhauer O, Schambach A, Asahara T, Steinhoff G.
EBioMedicine. 2020 Jul;57:102862. doi: 10.1016/j.ebiom.2020.102862. Epub 2020 Jul 4.  PubMed

Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.
Muenchhoff M, Mairhofer H, Nitschko H, Grzimek-Koschewa N, Hoffmann D, Berger A, Rabenau H, Widera M, Ackermann N, Konrad R, Zange S, Graf A, Krebs S, Blum H, Sing A, Liebl B, Wölfel R, Ciesek S, Drosten C, Protzer U, Boehm S, Keppler OT.
Euro Surveill. 2020 Jun 18; 25(24): 2001057. doi: 10.2807/1560-7917.ES.2020.25.24.2001057. PubMed

The clinical mutatome of core binding factor leukemia.
Opatz S, Bamopoulos SA, Metzeler KH, Herold T, Ksienzyk B, Bräundl K, Tschuri S, Vosberg S, Konstandin NP, Wang C, Hartmann L, Graf A, Krebs S, Blum H, Schneider S, Thiede C, Middeke JM, Stölzel F, Röllig C, Schetelig J, Ehninger G, Krämer A, Braess J, Görlich D, Sauerland MC, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA.
Leukemia. 2020 Jun;34(6):1553-1562. doi: 10.1038/s41375-019-0697-0. Epub 2020 Jan 2. PubMed

Sex-specific programming effects of parental obesity in pre-implantation embryonic development.
Hedegger K, Philippou-Massier J, Krebs S, Blum H, Kunzelmann S, Förstemann K, Gimpfl M, Roscher AA, Ensenauer R, Wolf E, Dahlhoff M.
Int J Obes (Lond). 2020 May;44(5):1185-1190. doi: 10.1038/s41366-019-0494-x. Epub 2019 Nov 27. PubMed

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.
Bamopoulos SA, Batcha AMN, Jurinovic V, Rothenberg-Thurley M, Janke H, Ksienzyk B, Philippou-Massier J, Graf A, Krebs S, Blum H, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Woermann BJ, Bohlander SK, Canzar S, Mansmann U, Hiddemann W, Braess J, Spiekermann K, Metzeler KH, Herold T.
Leukemia. 2020 May 1. doi: 10.1038/s41375-020-0839-4. Online ahead of print. PubMed

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.
Hedegger K, Stumpf F, Blum H, Graf A, Schmid RM, Lesina M, Algül H, Schneider MR, Dahlhoff M.
J Gastroenterol. 2020 Mar;55(3):317-329. doi: 10.1007/s00535-019-01613-6. Epub 2019 Aug 27. PubMed

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT.
Nature. 2020 Mar;579(7799):433-437. doi: 10.1038/s41586-020-2076-4. Epub 2020 Mar 4. PubMed

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.
Redondo Monte E, Wilding A, Leubolt G, Kerbs P, Bagnoli JW, Hartmann L, Hiddemann W, Chen-Wichmann L, Krebs S, Blum H, Cusan M, Vick B, Jeremias I, Enard W, Theurich S, Wichmann C, Greif PA.
Oncogene. 2020 Apr;39(15):3195-3205. doi: 10.1038/s41388-020-1209-4. Epub 2020 Mar 2. PubMed

The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties.
Hoesl C, Zanuttigh E, Fröhlich T, Philippou-Massier J, Krebs S, Blum H, Dahlhoff M. 
Biochim Biophys Acta Mol Cell Res. 2020 Aug;1867(8):118717. doi: 10.1016/j.bbamcr.2020.118717. Epub 2020 Apr 10. PubMed

Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D.
EMBO Mol Med. 2020 Feb 7;12(2):e10919. doi: 10.15252/emmm.201910919. Epub 2019 Dec 20. PubMed

Borrelia maritima sp. nov., a novel species of the Borrelia burgdorferi sensu lato complex, occupying a basal position to North American species.
Margos G, Fedorova N, Becker NS, Kleinjan JE, Marosevic D, Krebs S, Hui L, Fingerle V, Lane RS.
Int J Syst Evol Microbiol. 2020 Feb;70(2):849-856. doi: 10.1099/ijsem.0.003833. PubMed

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy.
Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C.
Nat Med. 2020 Feb;26(2):207-214. doi: 10.1038/s41591-019-0738-2. Epub 2020 Jan 27. PubMed

Shedding of Mycobacterium caprae by wild red deer (Cervus elaphus) in the Bavarian alpine regions, Germany.
Dorn-In S, Körner T, Büttner M, Hafner-Marx A, Müller M, Heurich M, Varadharajan A, Blum H, Gareis M, Schwaiger K.
Transbound Emerg Dis. 2020 Jan;67(1):308-317. doi: 10.1111/tbed.13353. Epub 2019 Sep 26. PubMed

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2019

Absolute nucleosome occupancy map for the Saccharomyces cerevisiae genome.
Oberbeckmann E, Wolff M, Krietenstein N, Heron M, Ellins JL, Schmid A, Krebs S, Blum H, Gerland U, Korber P.
Genome Res. 2019 Dec;29(12):1996-2009. doi: 10.1101/gr.253419.119. Epub 2019 Nov 6. PubMed

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis.
Beltrán E, Gerdes LA, Hansen J, Flierl-Hecht A, Krebs S, Blum H, Ertl-Wagner B, Barkhof F, Kümpfel T, Hohlfeld R, Dornmair K.
J Clin Invest. 2019 Nov 1;129(11):4758-4768. doi: 10.1172/JCI128475. PubMed

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia.
Batcha AMN, Bamopoulos SA, Kerbs P, Kumar A, Jurinovic V, Rothenberg-Thurley M, Ksienzyk B, Philippou-Massier J, Krebs S, Blum H, Schneider S, Konstandin N, Bohlander SK, Heckman C, Kontro M, Hiddemann W, Spiekermann K, Braess J, Metzeler KH, Greif PA, Mansmann U, Herold T.
Sci Rep. 2019 Aug 13;9(1):11796. doi: 10.1038/s41598-019-48167-4. PubMed

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.
Renner S, Martins AS, Streckel E, Braun-Reichhart C, Backman M, Prehn C, Klymiuk N, Bähr A, Blutke A, Landbrecht-Schessl C, Wünsch A, Kessler B, Kurome M, Hinrichs A, Koopmans SJ, Krebs S, Kemter E, Rathkolb B, Nagashima H, Blum H, Ritzmann M, Wanke R, Aigner B, Adamski J, Hrabe de Angelis M, Wolf E.
Dis Model Mech. 2019 Aug 12;12(8):dmm039156. doi: 10.1242/dmm.039156. PubMed

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E.
Mol Metab. 2019 Aug;26:30-44. doi: 10.1016/j.molmet.2019.05.011. Epub 2019 Jun 4. PubMed

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
Bastian L, Schroeder MP, Eckert C, Schlee C, Tanchez JO, Kämpf S, Wagner DL, Schulze V, Isaakidis K, Lázaro-Navarro J, Hänzelmann S, James AR, Ekici A, Burmeister T, Schwartz S, Schrappe M, Horstmann M, Vosberg S, Krebs S, Blum H, Hecht J, Greif PA, Rieger MA, Brüggemann M, Gökbuget N, Neumann M, Baldus CD.
Leukemia. 2019 Aug;33(8):1895-1909. doi: 10.1038/s41375-019-0430-z. Epub 2019 Mar 6. PubMed

The myelin protein PMP2 is regulated by SOX10 and drives melanoma cell invasion.
Graf SA, Heppt MV, Wessely A, Krebs S, Kammerbauer C, Hornig E, Strieder A, Blum H, Bosserhoff AK, Berking C.
Pigment Cell Melanoma Res. 2019 May;32(3):424-434. doi: 10.1111/pcmr.12760. Epub 2018 Dec 21. PubMed

Relative effects of location relative to the corpus luteum and lactation on the transcriptome of the bovine oviduct epithelium.
Locatelli Y, Forde N, Blum H, Graf A, Piégu B, Mermillod P, Wolf E, Lonergan P, Saint-Dizier M.
BMC Genomics. 2019 Mar 21;20(1):233. doi: 10.1186/s12864-019-5616-2. PubMed

Antigen-Specific TCR Signatures of Cytomegalovirus Infection.
Huth A, Liang X, Krebs S, Blum H, Moosmann A.
J Immunol. 2019 Feb 1;202(3):979-990. doi: 10.4049/jimmunol.1801401. Epub 2018 Dec 26. PubMed

MIR sequences recruit zinc finger protein ZNF768 to expressed genes.
Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D.
Nucleic Acids Res. 2019 Jan 25;47(2):700-715. doi: 10.1093/nar/gky1148. PubMed

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2018

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load.
Vosberg S, Hartmann L, Metzeler KH, Konstandin NP, Schneider S, Varadharajan A, Hauser A, Krebs S, Blum H, Bohlander SK, Hiddemann W, Tischer J, Spiekermann K, Greif PA.
Haematologica. 2018 Dec;103(12):e581-e584. doi: 10.3324/haematol.2018.193102. Epub 2018 Jun 28. PubMed

Correction: Comparative genomics and the nature of placozoan species.
Eitel M, Francis WR, Varoqueaux F, Daraspe J, Osigus HJ, Krebs S, Vargas S, Blum H, Williams GA, Schierwater B, Wörheide G.
PLoS Biol. 2018 Sep 19;16(9):e3000032. doi: 10.1371/journal.pbio.3000032. eCollection 2018 Sep. PubMed

Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing.
Baldi S, Krebs S, Blum H, Becker PB.
Nat Struct Mol Biol. 2018 Sep;25(9):894-901. doi: 10.1038/s41594-018-0110-0. Epub 2018 Aug 20. PubMed

Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia.
RSchranz K, Hubmann M, Harin E, Vosberg S, Herold T, Metzeler KH, Rothenberg-Thurley M, Janke H, Bräundl K, Ksienzyk B, Batcha AMN, Schaaf S, Schneider S, Bohlander SK, Görlich D, Berdel WE, Wörmann BJ, Braess J, Krebs S, Hiddemann W, Mansmann U, Spiekermann K, Greif PA.
Oncotarget. 2018 Jul 10;9(53):30128-30145. doi: 10.18632/oncotarget.25729. PubMed

Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation.
Rothammer S, Kunz E, Krebs S, Bitzer F, Hauser A, Zinovieva N, Klymiuk N, Medugorac I.
Genet Sel Evol. 2018 Jul 6;50(1):36. doi: 10.1186/s12711-018-0407-9. PubMed

Correction to: DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis.
La Fortezza M, Grigolon G, Cosolo A, Pindyurin A, Breimann L, Blum H, van Steensel B, Classen AK.
Epigenetics Chromatin. 2018 Jul 3;11(1):38. doi: 10.1186/s13072-018-0206-0. PubMed

IPEX due to an exon 7 skipping FOXP3 mutation with autoimmune diabetes mellitus cured by selective TReg cell engraftment.
Magg T, Wiebking V, Conca R, Krebs S, Arens S, Schmid I, Klein C, Albert MH, Hauck F.
Clin Immunol. 2018 Jun;191:52-58. doi: 10.1016/j.clim.2018.03.008. Epub 2018 Mar 19. PubMed

Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles.
Cheng Y, Jiang L, Keipert S, Zhang S, Hauser A, Graf E, Strom T, Tschöp M, Jastroch M, Perocchi F.
Cell Rep. 2018 Jun 5;23(10):3112-3125. doi: 10.1016/j.celrep.2018.05.021. PubMed

Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.
Schmidt EM, Lamprecht S, Blaj C, Schaaf C, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.
J Exp Med. 2018 Jun 4;215(6):1693-1708. doi: 10.1084/jem.20171455. Epub 2018 May 16. PubMed

Effects of single and combined low frequency electromagnetic fields and simulated microgravity on gene expression of human mesenchymal stem cells during chondrogenesis.
Mayer-Wagner S, Hammerschmid F, Blum H, Krebs S, Redeker JI, Holzapfel BM, Jansson V, Müller PE.
Arch Med Sci. 2018 Apr;14(3):608-616. doi: 10.5114/aoms.2016.59894. Epub 2016 May 16. PubMed

Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.
Schmähling S, Meiler A, Lee Y, Mohammed A, Finkl K, Tauscher K, Israel L, Wirth M, Philippou-Massier J, Blum H, Habermann B, Imhof A, Song JJ, Müller J.
Development. 2018 Apr 5;145(7):dev163808. doi: 10.1242/dev.163808. PubMed

Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.
Greif PA, Hartmann L, Vosberg S, Stief SM, Mattes R, Hellmann I, Metzeler KH, Herold T, Bamopoulos SA, Kerbs P, Jurinovic V, Schumacher D, Pastore F, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Graf A, Krebs S, Blum H, Neumann M, Baldus CD, Bohlander SK, Wolf S, Görlich D, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K.
Clin Cancer Res. 2018 Apr 1;24(7):1716-1726. doi: 10.1158/1078-0432.CCR-17-2344. Epub 2018 Jan 12. PubMed

OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.
Simmet K, Zakhartchenko V, Philippou-Massier J, Blum H, Klymiuk N, Wolf E.
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2770-2775. doi: 10.1073/pnas.1718833115. Epub 2018 Feb 26. PubMed

Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos.
Lavagi I, Krebs S, Simmet K, Beck A, Zakhartchenko V, Wolf E, Blum H.
Sci Rep. 2018 Mar 6;8(1):4071. doi: 10.1038/s41598-018-22248-2. PubMed

Exposure of pregnant sows to low doses of estradiol-17beta impacts on the transcriptome of the endometrium and the female preimplantation embryos.
Flöter VL, Bauersachs S, Fürst RW, Krebs S, Blum H, Reichenbach M, Ulbrich SE.
Biol Reprod. 2019 Mar 1;100(3):624-640. doi: 10.1093/biolre/ioy206. PubMed

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.
Herold T, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Ksienzyk B, Hartmann L, Greif PA, Philippou-Massier J, Krebs S, Blum H, Amler S, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Wörmann BJ, Tischer J, Subklewe M, Bohlander SK, Braess J, Hiddemann W, Metzeler KH, Mansmann U, Spiekermann K.
Haematologica. 2018 Mar;103(3):456-465. doi: 10.3324/haematol.2017.178442. Epub 2017 Dec 14. PubMed

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.
Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forné I, Decker TM, Martin D, Schüller R, Krebs S, Blum H, Imhof A, Eick D, Andrau JC.
Mol Cell. 2018 Jan 4;69(1):48-61.e6. doi: 10.1016/j.molcel.2017.12.009. PubMed

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2017

Detection of two non-synonymous SNPs in SLC45A2 on BTA20 as candidate causal mutations for oculocutaneous albinism in Braunvieh cattle.
Rothammer S, Kunz E, Seichter D, Krebs S, Wassertheurer M, Fries R, Brem G, Medugorac I.
Genet Sel Evol.
2017 Oct 5;49(1):73. doi: 10.1186/s12711-017-0349-7. PubMed

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.
Glaser LV, Rieger S, Thumann S, Beer S, Kuklik-Roos C, Martin DE, Maier KC, Harth-Hertle ML, Grüning B, Backofen R, Krebs S, Blum H, Zimmer R, Erhard F, Kempkes B.
PLoS Pathog.
2017 Oct 2;13(10):e1006664. doi: 10.1371/journal.ppat.1006664. eCollection 2017 Oct. PubMed

Effect of metabolic status on conceptus-maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.
Bauersachs S, Simintiras CA, Sturmey RG, Krebs S, Bick J, Blum H, Wolf E, Lonergan P, Forde N.
Biol Reprod.
2017 Sep 1;97(3):413-425. doi: 10.1093/biolre/iox095. PubMed

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 (I27N) mutant mice.
Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B.
J Biomed Sci. 2017 Aug 17;24(1):57. doi: 10.1186/s12929-017-0365-5. PubMed

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape.
Silva P, Neumann M, Schroeder MP, Vosberg S, Schlee C, Isaakidis K, Ortiz-Tanchez J, Fransecky LR, Hartung T, Türkmen S, Graf A, Krebs S, Blum H, Müller-Tidow C, Thiede C, Ehninger G, Serve H, Hecht J, Berdel WE, Greif PA, Röllig C, Baldus CD. 
Leukemia. 2017 Jul;31(7):1640-1644. doi: 10.1038/leu.2017.109. Epub 2017 Apr 3. PubMed

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.
Mol Metab.
2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug. PubMed

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.
Merk K, Breinig M, Böttcher R, Krebs S, Blum H, Boutros M, Förstemann K.
PLoS Genet. 2017 Jun 19;13(6):e1006861. doi: 10.1371/journal.pgen.1006861. eCollection 2017 Jun. PubMed

Investigation of intra-herd spread of Mycobacterium caprae in cattle by generation and use of a whole-genome sequence.
Broeckl S, Krebs S, Varadharajan A, Straubinger RK, Blum H, Buettner M.
Vet Res Commun. 2017 Jun;41(2):113-128. doi: 10.1007/s11259-017-9679-8. Epub 2017 Feb 13. PubMed

Investigation of intra-herd spread of Mycobacterium caprae in cattle by generation and use of a whole-genome sequence.
Broeckl S, Krebs S, Varadharajan A, Straubinger RK, Blum H, Buettner M.
Vet Res Commun. 2017 Jun;41(2):113-128. doi: 10.1007/s11259-017-9679-8. Epub 2017 Feb 13. PubMed

Lost in plasmids: next generation sequencing and the complex genome of the tick-borne pathogen Borrelia burgdorferi.
Margos G, Hepner S, Mang C, Marosevic D, Reynolds SE, Krebs S, Sing A, Derdakova M, Reiter MA, Fingerle V.
BMC Genomics. 2017 May 30;18(1):422. doi: 10.1186/s12864-017-3804-5. PubMed

Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.
Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D.
Sci Rep.
2017 May 10;7(1):1684. doi: 10.1038/s41598-017-01943-6. PubMed

Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks.
Medugorac I, Graf A, Grohs C, Rothammer S, Zagdsuren Y, Gladyr E, Zinovieva N, Barbieri J, Seichter D, Russ I, Eggen A, Hellenthal G, Brem G, Blum H, Krebs S, Capitan A.
Nat Genet. 2017 Mar;49(3):470-475. doi: 10.1038/ng.3775. Epub 2017 Jan 30. PubMed

TT-seq captures enhancer landscapes immediately after T-cell stimulation.
Michel M, Demel C, Zacher B, Schwalb B, Krebs S, Blum H, Gagneur J, Cramer P.
Mol Syst Biol. 2017 Mar 7;13(3):920. doi: 10.15252/msb.20167507. PubMed

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.
Woischke C, Schaaf CW, Yang HM, Vieth M, Veits L, Geddert H, Märkl B, Stömmer P, Schaeffer DF, Frölich M, Blum H, Vosberg S, Greif PA, Jung A, Kirchner T, Horst D.
Mod Pathol. 2017 Jan;30(1):95-103. doi: 10.1038/modpathol.2016.150. Epub 2016 Sep 2.. PubMed

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. PubMed

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.
Herold T, Metzeler KH, Vosberg S, Hartmann L, Jurinovic V, Opatz S, Konstandin NP, Schneider S, Zellmeier E, Ksienzyk B, Graf A, Krebs S, Blum H, Cristina Sauerland M, Büchner T, Berdel WE, Wörmann BJ, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K, Greif PA.
Genes Chromosomes Cancer. 2017 Jan;56(1):75-86. doi: 10.1002/gcc.22418. Epub 2016 Oct 25. PubMed

Effect of lactation on conceptus-maternal interactions at the initiation of implantation in cattle: I. Effects on the conceptus transcriptome and amino acid composition of the uterine luminal fluid.
Forde N, Simintiras CA, Sturmey RG, Graf A , Wolf E, Blum H , Lonergan P.
Biol Reprod.
2017 Jan 1;97(6):798-809. doi: 10.1093/biolre/iox135. PubMed

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2016

The 1.78-kb insertion in the 3'-untranslated region of RXFP2 does not segregate with horn status in sheep breeds with variable horn status.
Lühken G, Krebs S, Rothammer S, Küpper J, Mioč B, Russ I, Medugorac I.
Genet Sel Evol. 2016 Oct 19;48(1):78. doi: 10.1186/s12711-016-0256-3. PubMed

Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex.
Becker NS, Margos G, Blum H, Krebs S, Graf A, Lane RS, Castillo-Ramírez S, Sing A, Fingerle V.
BMC Genomics. 2016 Sep 15;17(1):734. doi: 10.1186/s12864-016-3016-4. PubMed

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.
Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D.
Blood. 2016 Sep 1;128(9):1246-59. doi: 10.1182/blood-2015-11-679167. Epub 2016 Jun 6. PubMed

Close Correlation of Copy Number Aberrations Detected by Next-Generation Sequencing with Results from Routine Cytogenetics in Acute Myeloid Leukemia.
Vosberg S, Herold T, Hartmann L, Neumann M, Opatz S, Metzeler KH, Schneider S, Graf A, Krebs S, Blum H, Baldus CD, Hiddemann W, Spiekermann K, Bohlander SK, Mansmann U, Greif PA.
Genes Chromosomes Cancer. 2016 Jul;55(7):553-67. doi: 10.1002/gcc.22359. Epub 2016 May 2. PubMed

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.
Nat Commun. 2016 Jun 2;7:11733. doi: 10.1038/ncomms11733. PubMed

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer.
Blaj C, Bringmann A, Schmidt EM, Urbischek M, Lamprecht S, Fröhlich T, Arnold GJ, Krebs S, Blum H, Hermeking H, Jung A, Kirchner T, Horst D.
Clin Cancer Res. 2017 Jun 1;23(11):2769-2780. doi: 10.1158/1078-0432.CCR-16-1604. Epub 2016 Nov 30. PubMed

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzeler K, Rothenberg-Thurley M, Schneider MR, Dahlhoff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander SK.
Leukemia. 2016 May;30(5):1166-76. doi: 10.1038/leu.2015.349. Epub 2015 Dec 21. PubMed

Trans-Atlantic exchanges have shaped the population structure of the Lyme disease agent Borrelia burgdorferi sensu stricto.
Castillo-Ramírez S, Fingerle V, Jungnick S, Straubinger RK, Krebs S, Blum H, Meinel DM, Hofmann H, Guertler P, Sing A, Margos G.
Sci Rep. 2016 Mar 9;6:22794. doi: 10.1038/srep22794. PubMed

Complete mitochondrial genome of Muricea crassa and Muricea purpurea (Anthozoa: Octocorallia) from the eastern tropical Pacific.
Poliseno A, Breedy O, Eitel M, Woerheide G, Guzman HM, Krebs S, Blum H, Vargas SR.
bioRxiv. 
2016 Mar. 24. doi: 10.1101/042945. bioRxiv

Mitochondrial genomes of the freshwater sponges Spongilla lacustris and Ephydatia cf. muelleri.
Francis WR, Eitel M, Vargas S, Krebs S, Blum H, Wörheide G.
Mitochondrial DNA Part B. 2016 Feb;1(1):250-51. doi: 10.1080/23802359.2016.1157771 Link

TRAPLINE: a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation.
Wolfien M, Rimmbach C, Schmitz U, Jung JJ, Krebs S, Steinhoff G, David R, Wolkenhauer O.
BMC Bioinformatics. 2016 Jan 6;17:21. doi: 10.1186/s12859-015-0873-9. PubMed

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2015

Melanocyte antigen triggers autoimmunity in human psoriasis.
Arakawa A, Siewert K, Stöhr J, Besgen P, Kim SM, Rühl G, Nickel J, Vollmer S, Thomas P, Krebs S, Pinkert S, Spannagl M, Held K, Kammerbauer C, Besch R, Dornmair K, Prinz JC.
J Exp Med. 2015 Dec 14;212(13):2203-12. doi: 10.1084/jem.20151093. Epub 2015 Nov 30. PubMed

Expression of microRNAs and isomiRs in the porcine endometrium: implications for gene regulation at the maternal-conceptus interface.
Krawczynski K, Bauersachs S, Reliszko ZP, Graf A, Kaczmarek MM.
BMC Genomics. 2015 Nov 6;16:906. doi: 10.1186/s12864-015-2172-2. PubMed

The Region of Difference Four is a Robust Genetic Marker for Subtyping Mycobacterium caprae Isolates and is Linked to Spatial Distribution of Three Subtypes.
Rettinger A, Broeckl S, Fink M, Prodinger WM, Blum H, Krebs S, Domogalla J, Just F, Gellert S, Straubinger RK, Büttner M.
Transbound Emerg Dis. 2017 Jun;64(3):782-792. doi: 10.1111/tbed.12438. Epub 2015 Oct 31. PubMed

Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation.
Lübking A, Vosberg S, Konstandin NP, Dufour A, Graf A, Krebs S, Blum H, Weber A, Lenhoff S, Ehinger M, Spiekermann K, Greif PA, Cammenga J.
Leuk Res Rep. 2015 Oct 17;4(2):72-5. doi: 10.1016/j.lrr.2015.10.001. eCollection 2015. PubMed

Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells.
Meyer SU, Krebs S, Thirion C, Blum H, Krause S, Pfaffl MW.
PLoS One. 2015 Oct 8;10(10):e0139520. doi: 10.1371/journal.pone.0139520. eCollection 2015. PubMed

Comparing effects of perfusion and hydrostatic pressure on gene profiles of human chondrocyte.
Zhu G, Mayer-Wagner S, Schröder C, Woiczinski M, Blum H, Lavagi I, Krebs S, Redeker JI, Hölzer A, Jansson V, Betz O, Müller PE.
J Biotechnol. 2015 Sep 20;210:59-65. doi: 10.1016/j.jbiotec.2015.06.409. Epub 2015 Jun 29. PubMed

Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation.
Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK.
Stem Cells Dev. 2015 Sep 15;24(18):2193-205. doi: 10.1089/scd.2014.0569. Epub 2015 Jun 25. PubMed

Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNF-α or IGF1.
Meyer SU, Sass S, Mueller NS, Krebs S, Bauersachs S, Kaiser S, Blum H, Thirion C, Krause S, Theis FJ, Pfaffl MW.
PLoS One.
2015 Aug 13;10(8):e0135284. doi: 10.1371/journal.pone.0135284. eCollection 2015. PubMed

GATA2 deficiency in children and adults with severe pulmonary alveolar proteinosis and hematologic disorders.
Griese M, Zarbock R, Costabel U, Hildebrandt J, Theegarten D, Albert M, Thiel A, Schams A, Lange J, Krenke K, Wesselak T, Schön C, Kappler M, Blum H, Krebs S, Jung A, Kröner C, Klein C, Campo I, Luisetti M, Bonella F.
BMC Pulm Med. 2015 Aug 12;15:87. doi: 10.1186/s12890-015-0083-2. PubMed

Parapoxvirus (PPV) of red deer reveals subclinical infection and confirms a unique species.
Friederichs S, Krebs S, Blum H, Lang H, Büttner M.
J Gen Virol. 2015 Jun;96(Pt 6):1446-1462. doi: 10.1099/vir.0.000080. Epub 2015 Feb 20. PubMed

Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications.
Popken J, Graf A, Krebs S, Blum H, Schmid VJ, Strauss A, Guengoer T, Zakhartchenko V, Wolf E, Cremer T.
PLoS One. 2015 May 1;10(5):e0124619. doi: 10.1371/journal.pone.0124619. eCollection 2015. PubMed

NGS population genetics analyses reveal divergent evolution of a Lyme Borreliosis agent in Europe and Asia.
Gatzmann F, Metzler D, Krebs S, Blum H, Sing A, Takano A, Kawabata H, Fingerle V, Margos G, Becker NS.
Ticks Tick Borne Dis. 2015 Apr;6(3):344-51. doi: 10.1016/j.ttbdis.2015.02.008. Epub 2015 Mar 10. PubMed

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.
Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S.
J Transl Med. 2015 Feb 25;13:73. doi: 10.1186/s12967-015-0431-2. PubMed

Zoonotic transmission of toxigenic Corynebacterium ulcerans strain, Germany, 2012.
Meinel DM, Konrad R, Berger A, König C, Schmidt-Wieland T, Hogardt M, Bischoff H, Ackermann N, Hörmansdorfer S, Krebs S, Blum H, Margos G, Sing A.
Emerg Infect Dis. 2015 Feb;21(2):356-8. doi: 10.3201/eid2102.141160. PubMed

Mutational spectrum of adult T-ALL.
Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD.
Oncotarget. 2015 Feb 20;6(5):2754-66. doi: 10.18632/oncotarget.2218. PubMed

Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy.
Lynch VJ, Nnamani MC, Kapusta A, Brayer K, Plaza SL, Mazur EC, Emera D, Sheikh SZ, Grützner F, Bauersachs S, Graf A, Young SL, Lieb JD, DeMayo FJ, Feschotte C, Wagner GP. 
Cell Rep. 2015 Feb 3;10(4):551-61. doi: 10.1016/j.celrep.2014.12.052. Epub 2015 Jan 29. PubMed

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2014

82 structural remodelling of the nuclear envelope in bovine pre-implantation embryos.
Popken J, Graf A, Krebs S, Blum H, Guengoer T, Zakhartchenko V, Wolf E, Cremer T.
Reprod Fertil Dev. 2014 Dec;27(1):134. doi: 10.1071/RDv27n1Ab82. Link

Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island.
Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A.
Genome Med. 2014 Nov 28;6(11):113. doi: 10.1186/s13073-014-0113-3. eCollection 2014. PubMed

Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos.
Popken J, Brero A, Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T.
Nucleus. 2014;5(6):555-89. doi: 10.4161/19491034.2014.979712. PubMed

Oxyphil cell metaplasia in the parathyroids is characterized by somatic mtDNA mutations in ND genes and COX- activity-impairing genes.
Müller-Höcker J, Schäfer S, Krebs S, Blum H, Zsurka G, Kunz WS, Prokisch H, Seibel P, Jung A.
Am J Pathol. 2014 Nov;184(11):2922-35. doi: 10.1016/j.ajpath.2014.07.015. PubMed

Genome activation in bovine embryos: Review of the literature and new insights from RNA sequencing experiments.
Graf A
, Krebs S, Heininen-Brown M, Zakhartchenko V, Blum H, Wolf E.
Anim Reprod Sci. 2014 Sep;149(1-2):46-58. doi: 10.1016/j.anireprosci.2014.05.016. Epub 2014 Jun 6. PubMed

Isolated trisomy 13 defines a genetically homogenous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.
Herold T, Metzeler KH, Vosberg S, Hartmann L, Röllig C, Stölzel F, Schneider S, Hubmann M, Zellmeier E, Ksienzyk B, Jurinovic V, Pasalic Z, Kakadia PM, Dufour A, Graf A, Krebs S, Blum H, Sauerland MC, Büchner T, Berdel WE, Woermann BJ, Bornhäuser M, Ehninger G, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K, Greif PA.
Blood. 2014 Aug 21;124(8):1304-11. doi: 10.1182/blood-2013-12-540716. Epub 2014 Jun 12. PubMed

Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men.
Schneider MR, Hiltwein F, Grill J, Blum H, Krebs S, Klanner A, Bauersachs S, Bruns C, Longerich T, Horst D, Brandl L, de Toni E, Herbst A, Kolligs FT.
Carcinogenesis. 2014 Aug;35(8):1855-62. doi: 10.1093/carcin/bgu109. Epub 2014 May 19. PubMed

Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements.
Samans B, Yang Y, Krebs S, Sarode GV, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U.
Dev Cell. 2014 Jul 14;30(1):23-35. doi: 10.1016/j.devcel.2014.05.023. Epub 2014 Jul 3. PubMed

FAT1 expression and mutations in adult acute lymphoblastic leukemia.
Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA, Baldus CD.
Blood Cancer J. 2014 Jun 27;4(6):e224. doi: 10.1038/bcj.2014.44. PubMed

Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.
Niess H, Camaj P, Renner A, Ischenko I, Zhao Y, Krebs S, Mysliwietz J, Jäckel C, Nelson PJ, Blum H, Jauch KW, Ellwart JW, Bruns CJ. 
Target Oncol. 2015 Jun;10(2):215-27. doi: 10.1007/s11523-014-0323-z. Epub 2014 Jun 22. PubMed

Programming and Isolation of Highly Pure Physiologically and Pharmacologically Functional Sinus-Nodal Bodies from Pluripotent Stem Cells.
Jung J, Husse B, Rimmbach C, Krebs S, Stieber J, Steinhoff G, Dendorfer A, Franz WM.
Stem Cell Reports. 2014 Apr 17;2(5):592-605. doi: 10.1016/j.stemcr.2014.03.006. eCollection 2014 May 6. PubMed

Complete Genome Sequence of a Wild-Type Measles Virus Isolated during the Spring 2013 Epidemic in Germany.
Sparrer KM, Krebs S, Jäger G, Santibanez S, Mankertz A, Blum H, Conzelmann KK.
Genome Announc. 2014 Apr 17;2(2):e00157-14. doi: 10.1128/genomeA.00157-14. PubMed

The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells.
Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Schneider MR, Blum H, Wagner E, Jung A, Gerhard M.
Carcinogenesis. 2014 Apr;35(4):942-50. doi: 10.1093/carcin/bgt410. Epub 2013 Dec 9. PubMed

Fine mapping of genome activation in bovine embryos by RNA sequencing.
Graf A
, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E.
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4139-44. doi: 10.1073/pnas.1321569111. Epub 2014 Mar 3. PubMed

Hypoxia-independent Gene Expression Mediated by Sox9 Promotes Aggressive Pancreatic Tumor Biology.
Camaj P, Jackel C, Krebs S, Detoni EN, Blum H, Jauch KW, Nelson PJ, Bruns CJ.
Mol Cancer Res. 2014 Mar;12(3):421-32. doi: 10.1158/1541-7786.MCR-13-0351. Epub 2013 Dec 3. PubMed

Comparative and retrospective molecular analysis of Parapoxvirus (PPV) isolates.
Friederichs S, Krebs S, Blum H, Wolf E, Lang H, von Buttlar H, Büttner M.
Virus Res. 2014 Mar 6;181:11-21. doi: 10.1016/j.virusres.2013.12.015. Epub 2013 Dec 27. PubMed

Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling.
Herbst A, Jurinovic V, Krebs S, Thieme SE, Blum H, Göke B, Kolligs FT.
BMC Genomics. 2014 Jan 28;15:74. doi: 10.1186/1471-2164-15-74.. PubMed

Generation and Characterization of a Porcine Model of Duchenne Muscular Dystrophy.
Blutke A, Klymiuk N, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Thirion C, Lochmüller H, Walter MC, Wolf E
Journal of Comparative Pathology. 2014 Jan; 150(1):80. doi: 10.1016/j.jcpa.2013.11.017. Link

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2013

Transcriptome changes in the porcine endometrium during the preattachment phase.
Samborski A
, Graf A, Krebs S, Kessler B, Reichenbach M, Reichenbach HD, Ulbrich SE, Bauersachs S.
Biol Reprod. 2013 Dec 12;89(6):134. doi: 10.1095/biolreprod.113.112177. Print 2013 Dec. PubMed

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.
Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E.
Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19. PubMed

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA. 
Blood.
 2013 Sep 5;122(10):1761-9. doi: 10.1182/blood-2013-01-476473. Epub 2013 Jul 22. PubMed

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells.
Fröhlich T, Kösters M, Graf A, Wolf E, Kobolak J, Brochard V, Dinnyés A, Jouneau A, Arnold GJ.
J Proteomics. 2013 Sep 2;90:38-51. doi: 10.1016/j.jprot.2013.03.015. Epub 2013 Apr 18. PubMed

Whole exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.
Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf AKrebs SBlum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD.
Blood. 2013 Jun 6;121(23):4749-52. doi: 10.1182/blood-2012-11-465138. Epub 2013 Apr 19. PubMed

Novel Insights into the Bovine Polled Phentoype and Horn Ontogenesis in Bovidae.
Allais-Bonnet A, Grohs C, Medugorac I, Krebs S, Djari A, Graf A, Fritz S, Seichter D, Baur A, Russ I, Bouet S, Rothammer S, Wahlberg P, Esquerré D, Hoze C, Boussaha M, Weiss B, Thépot D, Fouilloux M, Rossignol M, Marle-Köster E, Hreiðarsdóttir GE, Barbey S, Dozias D, Cobo E, Reversé P, Catros O, Marchand J, Soulas P, Roy P, Marquant-Leguienne B, Bourhis DL, Clément L, Salas-Cortes L, Venot E, Pannetier M, Phocas F, Klopp C, Rocha D, Fouchet M, Journaux L, Bernard-Capel C, Ponsart C, Eggen A, Blum H, Gallard Y, Boichard D, Pailhoux E, Capitan A.
PLoS One. 2013 May 22;8(5):e63512. doi: 10.1371/journal.pone.0063512. Print 2013. PubMed

Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs.
Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E.
Diabetes. 2013 May;62(5):1505-11. doi: 10.2337/db12-1065. Epub 2012 Dec 28. PubMed

Region of difference four (RD4) in Alpine Mycobacterium caprae isolates indicates three variants.
Domogalla J, Prodinger WM, Blum H, Krebs S, Gellert S, Müller M, Neuendorf E, Sedlmaier F, Büttner M.
J Clin Microbiol. 2013 May;51(5):1381-8. doi: 10.1128/JCM.02966-12. Epub 2013 Feb 13. PubMed

Differentially regulated microRNAs during human sebaceous lipogenesis.
Schneider MR, Samborski ABauersachs S, Zouboulis CC.
J Dermatol Sci. 2013 May;70(2):88-93. doi: 10.1016/j.jdermsci.2013.01.009. Epub 2013 Feb 9. PubMed

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V.
Immunity. 2013 Apr 18;38(4):655-68. doi: 10.1016/j.immuni.2012.12.004. Epub 2013 Apr 11. PubMed

Deep Sequencing of the Porcine Endometrial Transcriptome on Day 14 of Pregnancy.
Samborski A
, Graf A, Krebs S, Kessler B, Bauersachs S.
Biol Reprod. 2013 Apr 4;88(4):84. doi: 10.1095/biolreprod.113.107870. Print 2013 Apr. PubMed

Immune aspects of embryo-maternal cross-talk in the bovine uterus.
Bauersachs S,
Wolf E.
J Reprod Immunol. 2013 Mar;97(1):20-6. doi: 10.1016/j.jri.2012.11.002. PubMed

A Comprehensive Gene Expression Analysis of Resistance Formation upon Metronomic Cyclophosphamide Therapy.
Kubisch R, Meissner L, Krebs S, Blum H, Günther M, Roidl A, Wagner E.
Transl Oncol. 2013 Feb;6(1):1-9. doi: 10.1593/tlo.12295. Epub 2013 Feb 1. PubMed

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation.
Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B.
Cell. 2013 Jan 31;152(3):584-98. doi: 10.1016/j.cell.2013.01.009. PubMed

Transcriptional profiling to address molecular determinants of endometrial receptivity - Lessons from studies in livestock species.
Ulbrich SE, Groebner AE, Bauersachs S.
Methods. 2013 Jan;59(1):108-15. doi: 10.1016/j.ymeth.2012.10.013. PubMed

Detection and comparison of microRNA expression in the serum of Doberman Pinschers with dilated cardiomyopathy and healthy controls.
Steudemann C, Bauersachs S, Weber K, Wess G.
BMC Vet Res. 2013 Jan 17;9:12. doi: 10.1186/1746-6148-9-12. PubMed

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2012

Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.
Flisikowski K, Venhoranta H, Bauersachs S, Hänninen R, Fürst RW, Saalfrank A, Ulbrich SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M, Schnieke A.
Biol Reprod. 2012 Dec 21;87(6):140. doi: 10.1095/biolreprod.112.104240. Print 2012 Jun. PubMed

Exploration of global gene expression changes during the estrous cycle in equine endometrium.
Gebhardt S
, Merkl M, Herbach N, Wanke R, Handler J, Bauersachs S.
Biol Reprod. 2012 Dec 13;87(6):136. doi: 10.1095/biolreprod.112.103226. PubMed

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution.
Windhager L, Bonfert T, Burger K, Ruzsics Z, Krebs S, Kaufmann S, Malterer G, L'Hernault A, Schilhabel M, Schreiber S, Rosenstiel P, Zimmer R, Eick D, Friedel CC, Dölken L.
Genome Res. 2012 Oct;22(10):2031-42. doi: 10.1101/gr.131847.111. Epub 2012 Apr 26. PubMed

Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression.
Tirado-González I, Barrientos G, Freitag N, Otto T, Thijssen VL, Moschansky P, von Kwiatkowski P, Klapp BF, Winterhager E, Bauersachs S, Blois SM.
PLoS One. 2012;7(10):e46755. doi: 10.1371/journal.pone.0046755. Epub 2012 Oct 8. PubMed

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase.
Bauersachs S
, Wolf E.
Anim Reprod Sci. 2012 Sep;134(1-2):84-94. doi: 10.1016/j.anireprosci.2012.08.015. Epub 2012 Aug 11. PubMed

Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass.
Renner S, Römisch-Margl W, Prehn C, Krebs S, Adamski J, Göke B, Blum H, Suhre K, Roscher AA, Wolf E.
Diabetes. 2012 Aug;61(8):2166-75. doi: 10.2337/db11-1133. Epub 2012 Apr 9. PubMed

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.
Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dörge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK.
Blood. 2012 Jul 12;120(2):395-403. doi: 10.1182/blood-2012-01-403220. Epub 2012 May 30.PubMed

Bovine polledness - an autosomal dominant trait with allelic heterogeneity.
Medugorac I, Seichter D, Graf A, Russ I, Blum H, Göpel KH, Rothammer S, Förster M, Krebs S.
PLoS One. 2012;7(6):e39477. doi: 10.1371/journal.pone.0039477. Epub 2012 Jun 21. PubMed

Hosting the preimplantation embryo: potentials and limitations of different approaches for analysing embryo-endometrium interactions in cattle.
Ulbrich SE, Wolf E, Bauersachs S.
Reprod Fertil Dev. 2012;25(1):62-70. doi: 10.1071/RD12279. PubMed

Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium.
Bauersachs S
, Ulbrich SE, Reichenbach HD, Reichenbach M, Büttner M, Meyer HH, Spencer TE, Minten M, Sax G, Winter G, Wolf E.
Biol Reprod. 2012 Feb 29;86(2):46. doi: 10.1095/biolreprod.111.094771. Print 2012 Feb. PubMed

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in release of foetal membranes.
Streyl D, Kenngott R, Herbach N, Wanke R, Blum H, Sinowatz F, Wolf E, Zerbe H, Bauersachs S.
Reproduction. 2012 Jan 1;143(1):85-105. doi: 10.1530/REP-11-0204. Epub 2011 Oct 26. PubMed

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2011

Reduced Amino Acids in the Bovine Uterine Lumen of Cloned versus In Vitro Fertilized Pregnancies Prior to Implantation.
Groebner AE, Zakhartchenko V, Bauersachs S, Rubio-Aliaga I, Daniel H, Büttner M, Reichenbach HD, Meyer HH, Wolf E, Ulbrich SE.
Cell Reprogram. 2011 Oct;13(5):403-10. doi: 10.1089/cell.2011.0006. Epub 2011 Jul 20. PubMed

Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing.
Greif PA, Yaghmaie M, Konstandin NP, Ksienzyk B, Alimoghaddam K, Ghavamzadeh A, Hauser A, Graf A, Krebs S, Blum H and Bohlander SK.
Leukemia. 2011 Sep;25(9):1519-22. doi: 10.1038/leu.2011.114. Epub 2011 May 24. PubMed

Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling.
Pimentel EC, Bauersachs S, Tietze M, Simianer H, Tetens J, Thaller G, Reinhardt F, Wolf E, König S.
Anim Genet. 2011 Jun;42(3):251-62. doi: 10.1111/j.1365-2052.2010.02148.x. Epub 2010 Dec 30. PubMed

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium.
Bauersachs S
, Ulbrich SE, Reichenbach HD, Reichenbach M, Büttner M, Meyer HH, Spencer TE, Minten M, Sax G, Winter G, Wolf E.
Biol Reprod. 2012 Feb 29;86(2):46. doi: 10.1095/biolreprod.111.094771. PubMed

Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor necrosis factor alpha.
Gunther J, Esch K, Poschadel N, Petzl W, Zerbe H, Mitterhuemer S, Blum H, Seyfert HM. 
Infect Immun. 2011 Feb;79(2):695-707. doi: 10.1128/IAI.01071-10. Epub 2010 Nov 29. PubMed

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Büttner M, Fröhlich T, Arnold G, Reichenbach HD, Wolf E, Meyer HH.
Mol Cell Endocrinol. 2011 Jan 30;332(1-2):48-57. doi: 10.1016/j.mce.2010.09.009. Epub 2010 Sep 29. PubMed

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2010

Actions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium.
Shimizu T, Krebs S, Bauersachs S, Blum H, Wolf E, Miyamoto A.
Physiol Genomics. 2010 Nov 29;42A(4):290-300. doi: 10.1152/physiolgenomics.00107.2010. Epub 2010 Sep 28. PubMed

Microarray Analysis of Equine Endometrium at Days 8 and 12 of Pregnancy.
Merkl M
, Ulbrich SE, Otzdorff C, Herbach N, Wanke R, Wolf E, Handler J, Bauersachs S.
Biol Reprod. 2010 Nov;83(5):874-86. doi: 10.1095/biolreprod.110.085233. Epub 2010 Jul 14. PubMed

Differential endometrial gene expression in pregnant and nonpregnant sows.
Ostrup E, Bauersachs S, Blum H, Wolf E, Hyttel P. 
Biol Reprod. 2010 Aug 1;83(2):277-85. doi: 10.1095/biolreprod.109.082321. Epub 2010 Apr 14. PubMed

Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland.
Mitterhuemer S
, Petzl W, Krebs S, Mehne D, Klanner A, Wolf E, Zerbe H, Blum H
BMC Genomics. 2010 Feb 25;11:138. doi: 10.1186/1471-2164-11-138. PubMed

Creating new knowledge for ruminant reproduction from rapidly expanding and evolving scientific databases.
Bauersachs S
, Blum H, Krebs S, Fröhlich T, Arnold GJ, Wolf E.
Soc Reprod Fertil Suppl. 2010;67:29-40. PubMed

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2009

EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
Camaj P, Seeliger H, Ischenko I, Krebs S, Blum H, De Toni EN, Faktorova D, Jauch KW, Bruns CJ. 
Biol Chem 390. 2009 Dec;390(12):1293-302. doi: 10.1515/BC.2009.140. PubMed

Evidence for Estrogen-Dependent Uterine Serpin (SERPINA14) Expression During Estrus in the Bovine Endometrial Glandular Epithelium and Lumen.
Ulbrich SE, Frohlich T, Schulke K, Englberger E, Waldschmitt N, Arnold GJ, Reichenbach HD, Reichenbach M, Wolf E, Meyer HHD, Bauersachs S.
Biol Reprod 2009 Oct;81(4):795-805. doi: 10.1095/biolreprod.108.075184. Epub 2009 Jun 3. PubMed

Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
Baehs S, Herbst A, Thieme SE, Perschl C, Behrens A, Scheel S, Jung A, Brabletz T, Goke B, Blum H, Kolligs FT. 
Cancer Lett. 2009 Apr 18;276(2):152-9. doi: 10.1016/j.canlet.2008.11.003. Epub 2008 Dec 6. PubMed

The endometrium responds differently to cloned versus fertilized embryos.
Bauersachs S
, Ulbrich SE, Zakhartchenko V, Minten M, Reichenbach M, Reichenbach HD, Blum H, Spencer TE, Wolf E
Proc Natl Acad Sci U S A2009 Apr 7;106(14):5681-6. doi: 10.1073/pnas.0811841106. Epub 2009 Mar 23. PubMed

A simple and loss-free method to remove TRIzol contaminations from minute RNA samples.
Krebs S, Fischaleck M, Blum H

Anal Biochem. 2009 Apr 1;387(1):136-8. doi: 10.1016/j.ab.2008.12.020. Epub 2008 Dec 25. PubMed

EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma.
Seeliger H, Camaj P, Ischenko I, Kleespies A, De Toni EN, Thieme SE, Blum H, Assmann G, Jauch KW, Bruns CJ. 
Mol Cancer Res. 2009 Feb;7(2):189-98. doi: 10.1158/1541-7786.MCR-08-0132. Epub 2009 Feb 10. PubMed

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2008

OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer.
De Toni EN, Thieme SE, Herbst A, Behrens A, Stieber P, Jung A, Blum H, Goke B, Kolligs, FT.
Clin Cancer Res. 2008 Aug 1;14(15):4713-8. doi: 10.1158/1078-0432.CCR-07-5019. PubMed

Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy.
Bauersachs S, Mitko K
, Ulbrich SE, Blum H, Wolf E.
Exp Clin Endocrinol Diabetes. 2008 Jul;116(7):371-84. doi: 10.1055/s-2008-1076714. Epub 2008 Jun 17. PubMed

Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle.
Mitko, K
, Ulbrich SE, Wenigerkind H, Sinowatz F, Blum H, Wolf E, Bauersachs S
Reproduction. 2008 Feb;135(2):225-40. doi: 10.1530/REP-07-0415. PubMed

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2007

Technical note: Bovine oviduct and endometrium array version 1: a tailored tool for studying bovine endometrium biology and pathophysiology.
Bauersachs S
, Mitko K, Blum H, Wolf E
J Dairy Sci. 2007 Sep;90(9):4420-3. doi: 10.3168/jds.2007-0132. PubMed

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2006

Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity.
Bauersachs S
, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Wenigerkind H, Vermehren M, Sinowatz F, Blum H, Wolf E.
Reproduction. 2006 Aug;132(2):319-31. doi: 10.1530/rep.1.00996. PubMed

Purification of His-tagged hybrid phage antibody.
Donzeau M, Bauersachs S, Blum H, Reichelt P, Rohnisch T, Nagel W.
Anal Biochem. 2006 May 1;352(1):154-6. doi: 10.1016/j.ab.2005.12.020. Epub 2006 Jan 13. PubMed

Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro.
Ulbrich SE, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, Vermehren M, Sinowatz F, Meyer HH, Einspanier R.
J Endocrinol. 2006 Feb;188(2):205-13. doi: 10.1677/joe.1.06526. PubMed

Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period.
Klein C
, Bauersachs S, Ulbrich SE, Einspanier R, Meyer HH, Schmidt SE, Reichenbach HD, Vermehren M, Sinowatz F, Blum H, Wolf E
Biol Reprod. 2006 Feb;74(2):253-64. doi: 10.1095/biolreprod.105.046748. Epub 2005 Oct 5. PubMed

Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle.
Wolf E
, Hiendleder S, Bauersachs S, Frohlich T, Sinowatz F, Blum H, Arnold GJ.
Berl Munch Tierarztl Wochenschr. 2006 Jan-Feb;119(1-2):7-16. PubMed

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2005

Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes.
Bauersachs S
, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Einspanier R, Wenigerkind H, Vermehren M, Blum H, Sinowatz F, Wolf E.
J Mol Endocrinol. 2005 Jun;34(3):889-908. doi: 10.1677/jme.1.01799. PubMed

Functional genomics: tools for improving farm animal health and welfare.
Hiendleder S, Bauersachs S, Boulesteix A, Blum H, Arnold GJ, Frohlich T, Wolf E.
Rev Sci Tech. 2005 Apr;24(1):355-77. PubMed

Transcriptome analysis of a human colorectal cancer cell line shows molecular targets of insulin-like growth factor-binding protein-4 overexpression.
Diehl D, Lahm H, Wolf E, Bauersachs S.
Int J Cancer. 2005 Feb;113(4):588-99. doi: 10.1002/ijc.20580. PubMed

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2004

Monitoring gene expression changes in bovine oviduct epithelial cells during the oestrous cycle.
Bauersachs S, Rehfeld S, Ulbrich SE, Mallok S, Prelle K, Wenigerkind H, Einspanier R, Blum H, Wolf E.
J Mol Endocrinol. 2004 Apr;32(2):449-466. doi: 10.1677/jme.0.0320449. PubMed

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2003

Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk.
Wolf E
, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Frohlich T, Herrler A, Hiendleder S, Kolle S, Prelle K, Reichenbach HD, Stojkovic M, Wenigerkind H, Sinowatz F.
Reprod Domest Anim. 2003 Aug;38(4):276-89. doi: 10.1046/j.1439-0531.2003.00435.x. PubMed

Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach. 
Bauersachs S., Blum H., Mallok S., Wenigerkind H., Rief S., Prelle K. and Wolf E.
Biol Reprod. 2003 Apr;68(4):1170-7. doi: 10.1095/biolreprod.102.010660. PubMed

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2001

Sequences and replication of genomes of the archaeal rudiviruses SIRV1 and SIRV2: relationships to the archaeal lipothrixvirus SIFV and some eukaryal viruses.
Peng X, Blum H, She Q, Mallok S, Brügger K, Garrett RA, Zillig W, Prangishvili D
Virology. 2001 Dec 20;291(2):226-34. doi: 10.1006/viro.2001.1190. PubMed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A.(2001)
Genome Res. 2001 Mar;11(3):422-435. doi: 10.1101/gr.gr1547r. PubMed

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